منابع مشابه
Hemoglobin-facilitated diffusion of oxygen: interfacial and thickness effects.
The equations of facilitated diffusion were solved numerically for steady state diffusion of oxygen across membranes of hemoglobin and myoglobin. An interfacial resistance was included in the boundary conditions and the dependence of the solutions on membrane thickness and interfacial conductance was studied. The data of Wittenberg on millipore membranes was fitted adequately if a tortuosity fa...
متن کاملThe molecular mechanism of hemoglobin-facilitated oxygen diffusion.
Hemoglobin in solution augments the rate of steady state diffusion of oxygen. The flux of oxygen exceeds the diffusive flux by an amount, the facilitated flux, which is constant for a given hemoglobin concentration and is invariant with changing oxygen tension. The facilitated flux is inversely proportional to the length of the diffusion path. Facilitation decreases with increasing molecular si...
متن کاملFacilitated diffusion on confined DNA.
In living cells, proteins combine three-dimensional bulk diffusion and one-dimensional sliding along the DNA to reach a target faster. This process is known as facilitated diffusion and we investigate its dynamics in the physiologically relevant case of confined DNA. The confining geometry and DNA elasticity are key parameters: We find that facilitated diffusion is most efficient inside an isot...
متن کاملFacilitated diffusion with DNA coiling.
When DNA-binding proteins search for their specific binding site on a DNA molecule they alternate between linear 1-dimensional diffusion along the DNA molecule, mediated by nonspecific binding, and 3-dimensional volume excursion events between successive dissociation from and rebinding to DNA. If the DNA molecule is kept in a straight configuration, for instance, by optical tweezers, these 3-di...
متن کاملEnergetic funnel facilitates facilitated diffusion
Transcription factors (TFs) are able to associate to their binding sites on DNA faster than the physical limit posed by diffusion. Such high association rates can be achieved by alternating between three-dimensional diffusion and one-dimensional sliding along the DNA chain, a mechanism-dubbed facilitated diffusion. By studying a collection of TF binding sites of Escherichia coli from the Regulo...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42483-6